What is the best Vitamin Stack for Acne?

Acne can be an embarrassing and uncomfortable condition. In many cases, it’s extremely persistent, and sufferers find themselves spending huge amounts of time and money to reduce occurrences of acne.

What if there was a more effective way to calm your acne? What if you could simply up your vitamin and mineral intake, or in other words, get healthier all around?

This solution may be more feasible than it seems. There are many vitamins and minerals that support healthy skin, and most are available in supplement form. We’re going to take a look at which vitamins and minerals may help and check out the best vitamin stack for acne.

What is Acne?

Acne is a skin condition triggered by overproduction of sebum or oil by the sebaceous glands (source). This build up of oil on the skin leads to clogging of pores (tiny holes in the surface of the skin) with dead skin and bacteria. As the blockage progresses, the inflammatory process begins - leading to redness, pain and swelling.

Depending on the exact structure of the blockage, it will appear as a blackhead or whitehead. A whitehead is a small pocket of pus under the skin which appears as a white bump. If the pus is exposed to air, its coloring turns darker and it becomes a blackhead.

In more severe cases, presence of the bacteria P. Acnes leads to larger pustules, nodules and cysts.

Related- The Best Foods to Clear Acne

What Causes Acne?

As we have discussed, the direct cause of acne is clogged pores due to overproduction of sebum. However, there’s much more to the story than that. Hormones have a significant effect on the development of persistent acne.

Genetics may also play a role in the development of acne. If your parents or siblings suffered from acne, you’re more likely to be affected too. Some medications can also cause acne or worsen an existing condition.

What are the Traditional Treatments for Acne?

Acne is frequently treated through the use of facial cleansers, treatments, toners, masks, or moisturizers that contain proven over the counter acne-fighting ingredients like benzoyl peroxide or salicylic acid. Good hygiene habits, like washing face and hair daily and not touching the face, may also help.

Many people find that visiting a dermatologist is the best way to effectively treat acne. For serious cases, it’s definitely ideal to have a medical professional to provide some guidance.

Eating a healthy diet is also thought by many to help improve acne. Avoiding greasy foods or chocolate probably won’t be as helpful as many old wives’ tales suggest, but eating a balanced diet full of healthy, antioxidant-rich fruits and vegetables, good fats, and hearty protein just might.

Who Does Acne Affect?

Most people think of teenagers when they think of acne sufferers. It’s absolutely true that teenagers are the most likely to experience acne due to hormonal fluctuations (and sometimes poor hygiene habits), but it’s also true that a fair majority of the population experience acne at some point or another.

Adult acne is far more common that most people think, and 80% of people between 11 and 30 report suffering from acne (source). People who are under a great deal of stress, those experiencing hormone fluctuations due to medications or life changes, and people who are exposed to air pollution are also at higher risk.

Which Vitamins, Minerals, and Other Supplements are Good for Acne?

There are several vitamins, minerals, and nutrients that may help maintain healthy skin and prevent or even treat acne. Generally speaking, substances with anti-inflammatory properties are ideal.

How does Zinc Help Acne?

Zinc is thought to help acne by aiding in the balancing of hormones, a common cause of overactive sebaceous glands. Studies have found oral zinc supplementation to be effective (source). Many people are deficient in the mineral zinc, so even if it doesn’t cure your acne, it will most likely benefit overall health.

What can Vitamin A do for Acne?

Vitamin A is a substance known for its skin benefits. Retinol, a well-known ingredient in many “miracle” skin creams, is actually a derivative of vitamin A. Studies have shown that they may be helpful when taken internally too (source). Vitamin A may be helpful for acne sufferers due to its role in healing wounds.

How Can Vitamin E Help?

Vitamin E is an antioxidant, meaning it helps eliminate free radicals that cause damage to our skin. It also helps with blood flow and the immune system, which may help keep infection from occurring in the sebaceous glands (source).

It is also thought that vitamin E deficiency may be at least partially responsible for acne (source). This means that supplementing it, or increasing your vitamin E-rich food intake at the very least, may be beneficial.

What Affects can Vitamin B3 Have on Acne?

Vitamin B3, also known as niacin, also plays a role in hormone production and regulation. Because of this, it’s worth looking for to find the best vitamin stack for acne. Beware of flushing (redness and warmth) of the skin when using niacin (source).

Warnings about Using Supplements to Treat Acne

Always speak to your physician before starting any vitamin, mineral, or other supplements. This is especially important if you are taking any prescription medicines or have any other long term health conditions.

Vitamin E is often thought of as a premier acne supplement ingredient, but be wary. Large doses of vitamin E taken internally can cause bleeding - even in the brain! Therefore it’s vital to consult your doctor before using any type of vitamin E supplement.

Stick to recommended dosages, and check out the upper intake levels of each ingredient in a new supplement for your gender and age against the dosage the supplement contains. While many of the above ingredients are water soluble and leave the body quickly, some are not and may cause toxicity.

How to Choose the Best Vitamin Stack for Acne

Look for a supplement that contains several of the acne-fighting vitamins, minerals, and other ingredients that we’ve already talked about. Choose a supplement that is made in a GMP (good manufacturing practice for pharmaceuticals) certified facility, is third party tested, and is made by a reputable manufacturer. Aside from these things, find a supplement that works for you. The size of the capsules, dosages, price, and dosage times per day are personal preferences.

ClearZine Acne Solution



Our rating

This acne fighting supplement is intended as a total acne treatment, meaning it prevents, treats, and reduces the after effects of acne breakouts. It is manufactured in a GMP certified facility, and it contains many of the recommended vitamins listed above.


  • Vitamin B5 works to regulate hormones
  • All natural ingredients
  • Less harsh than prescription acne medications
  • Suitable for acne sufferers of all ages
  • Improves hair quality too


  • Large, sticky capsules are hard to swallow
  • Must take large doses at first
  • May cause skin drying
  • Stomach upset may occur

Vie Naturelle Acne Treatment Supplement



Our rating

This all natural dietary supplement contains tons of acne-fighting ingredients. The manufacturer claims that this product will produce speedy results.


  • High concentrations of acne-fighting ingredients
  • No fillers
  • Ingredients backed by scientific research
  • Good for all ages
  • Reduced skin oiliness


  • Up to 3 pills a day
  • Many find results slow to appear
  • May not work for every user

Murad Pure Skin Clarifying Dietary Supplement



Our rating

This supplement uses a combination of vitamin A, zinc, herbal remedies, and many other vitamins and minerals that have been found effective in treating acne.


  • No artificial ingredients
  • Wide range of ingredients
  • No animal testing
  • Possibly effective in treating hormonal acne
  • No major allergens


  • Must take 4 pills daily
  • May cause stomach upset
  • Herbal ingredients may interfere with medications
  • May cause dehydration

Addrena Acnetame



Our rating

This supplement claims to be the best over the counter acne treatment on the market. It uses a combination of vitamins, minerals, and amino acids to treat acne from the inside out.


  • Formulated to help hormonal acne
  • Smaller dosage required
  • Works in conjunction with skin care routine
  • Decreases oil production
  • All natural ingredients


  • Sulphur smell can be unbearable
  • May cause excessive skin drying
  • Takes time to work
  • May cause hair loss

ClearBiotic Complete Complex



Our rating

This supplement takes a unique approach to clearing up acne by adding in a probiotic. Probiotics are “good” bacteria thought to fight off infection and help any number of health problems. This product also utilizes many of the vitamins discussed earlier, so it’s a fairly complete approach to curing acne.


  • Unique probiotic formula
  • Addresses root cause of inflammation
  • Contains many vitamins for healthy skin
  • Great for acne caused by antibiotic use


  • May cause digestive difficulties
  • Should be taken with meals
  • Cost prohibitive
  • Lacks trace minerals


The clear winner in the best vitamin stack for acne contest is the Vie Naturelle supplement. It contains all of the acne fighting ingredients we looked at and is made by a reputable company.

If you’ve suffered from acne and tried every skincare product and prescription medication out there, I strongly encourage you to consider an internal approach, taking into account your overall skin health. If you have any questions about vitamins for acne, or any other health subject, don’t hesitate to ask us!

Helen Sanders

Chief editor here at Health Ambition, I'm a proud mother of two passionate about nutrition and ways to live healthier with more energy!

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