Best Supplement Stack for Depression?

A very depressed woman with the title "Best Vitamin Stack for Depression?"

You’ve all heard the expression “you are what you eat”right? Modern nutrition is beginning to realise that getting enough vitamins and minerals can affect not only our physical health, but our mental health too.

Depression is one mental health condition that many believe can be improved through the use of vitamins. At the very least, providing vitamins that nourish your brain won’t make depression symptoms any worse.

We’ll go over the best supplement stack for depression here, and I’ll let you in on why the individual components may help support sufferers.

Product
Details
Our Rating
Our #1 Rated
HCF Happy Calm Focused Brain Supplement

HCF

HCF Happy Calm Focused Brain Supplement

5 out of 5

In the Depression Supplements category

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  • REGULAR STRENGTH BRAIN SUPPLEMENT - HCF Happy, Calm & Focused brain nootropic (fueled by FQ amino-acids & 15+ pure &...
  • ENHANCE COGNITION & BOOST MENTAL PERFORMANCE* - Helps enhance focus*, helps increase attention*, helps improve alertness &...
  • ORIGINAL, EFFECTIVE & PURE FORMULA - HCF Happy, Calm & Focused is hypoallergenic, and contains the purest neuro-nutrients...
HealthAmbition Stamp

Our #1 Rated

5 out of 5

In the Depression Supplements category


Our #2 Rated
Brain Boost by BioScience Nutrition

Arazo Nutrition

Brain Boost by BioScience Nutrition

4 out of 5

In the Depression Supplements category

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  • SCIENTIFICALLY FORMULATED - We carefully combined just the right amount of 41 ingredients into a premium formula designed to...
  • FOCUS, MEMORY & CLARITY - Brain Plus is an all-natural Nootropic, formulated to help support memory and cognition. The...
  • STRESS & MOOD SUPPORT- Designed to increase your mental performance, promote positive mood, increase natural energy and ramp...
HealthAmbition Stamp

Our #2 Rated

4 out of 5

In the Depression Supplements category


Our #3 Rated
Natural Mood Lift by Nested Naturals

Nested Naturals

Natural Mood Lift by Nested Naturals

4 out of 5

In the Depression Supplements category

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  • LOVE OUR MOOD LIFT OR YOUR MONEY BACK | Hello, we're Nested Naturals. Nice to meet you! We're a socially conscious company...
  • FEELING OUT OF SORTS CAN BE RELATED TO NUTRITION: The brain needs a variety of micronutrients to produce the chemicals that...
  • A HARMONIOUS FORMULA OF MOOD BOOSTING AMINO ACIDS: Our Mood Lift uses a blend of 5-HTP, L-Methionine, Magnesium, Vitamin B5...
HealthAmbition Stamp

Our #3 Rated

4 out of 5

In the Depression Supplements category


Our #4 Rated
BoostMood Natural Mood Support

InstantBrands

BoostMood Natural Mood Support

3 out of 5

In the Depression Supplements category

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  • Strongest natural mood, anxiety and stress support supplement.
  • Maximum strength natural ingredients. Increase and regulate your serotonin and GABA naturally.
  • The highest dosage of all the ingredients than any other mood formula.
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Our #4 Rated

3 out of 5

In the Depression Supplements category


Our #5 Rated
Mood Boost by LES Labs

LES Labs

Mood Boost by LES Labs

2 out of 5

In the Depression Supplements category

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  • NATURAL CALMING MOOD SUPPLEMENT. Mood Boost's natural formula helps to provide stress and anxiety relief quickly.
  • PROMOTES POSITIVE MOOD. 5-HTP naturally promotes positive mood. L-Tyrosine and L-Theanine help to relieve stress and anxiety....
  • STRESS RELIEVING HERBAL BLEND. Passion flower, ashwagandha, rhodiola rosea, and chamomile extracts are packed into Mood Boost...
HealthAmbition Stamp

Our #5 Rated

2 out of 5

In the Depression Supplements category

What is Depression?

Depression is a common mood disorder that is characterized by feelings of sadness, emptiness, or hopelessness. Other symptoms may include irritability, restlessness, changes in eating or sleeping patterns, loss of interest in normally enjoyable activities, fatigue and body pains. (source)

The clinical requirements for the diagnosis of depression is experiencing some or all of the above symptoms every day for two weeks or more.

What Causes Depression?

The cause of depression is thought to be a combination of environmental factors and imbalances in brain chemistry. It’s important to note that depression doesn’t look or feel the same for every person. Part of that is that there are several types of depression.

Some depression is potentially caused by hormonal imbalances or fluctuations, including pregnancy. Some illnesses such as thyroid disorders or medications may also contribute to depression symptoms.

Who Experiences this Condition?

Anyone can suffer from depression. Young or old, male or female, people from all socioeconomic and racial backgrounds may experience depression. No one is immune to depression.

There are people who are at a higher risk of experiencing depression. People with a family history or who have been diagnosed with depression before are at a higher risk. Those experiencing major life changes and upsets are also at risk.

Which Vitamins or Supplements May Help?

There are several vitamins that are thought to help with depression, with various levels of evidence to support them. We’ll go over some of the supplements that have been studied and have been proven to be effective for those with depression.

B vitamins, vitamin D, omega-3 fatty acids, magnesium, and zinc are all thought to be effective on some level. It’s crucial to note that vitamins and supplements are not a replacement for depression medications and therapies.

How Can B Vitamins Help?

B Vitamins like B12 and folate play a significant role in the production of many chemicals that work in the brain, including some that affect mood. (source) Low folate and B12 levels have been found in patients who exhibit signs of depression. While results aren’t totally conclusive, there’s evidence to suggest it works.

What Makes Fish Oil Good for Depression?

The omega-3 fatty acids in fish oil are important to the health of your brain. They also cannot be synthesized in the body. If you don’t eat much fish, fish oil supplements are ideal for supplying the DHA and EPA omega-3s you need. While fish oil is not an approved treatment for depression, it won’t hurt. (source)

How Does Vitamin D Help?

Studies have shown that people who have depression are also deficient in vitamin D. This suggests that it may be at least partially behind depressive symptoms. (source) Vitamin D affects hormones and other brain chemicals. Our bodies can synthesize vitamin D so long as we are exposed to enough sunlight.

Can Magnesium Be Used for Depression?

Modern diets are often lacking in magnesium, so supplementing this mineral might be a good idea. There is some evidence to suggest that supplementing magnesium may help to stabilize moods, and since most Americans are deficient anyways, there’s likely no harm.

This mineral is often found in topical forms of supplementation, as well. It has long been known as a great supplement for mood support, so if you must pick one ingredient to look for in a mood enhancing supplement, this is probably the one.

Mg spelled with tablets

What Makes Zinc Good for Depression?

At least one study has shown that zinc supplementation may also aid in the improvement of depressive symptoms, alongside antidepressant medications. Once again, most American diets are deficient in zinc, so supplementing won’t hurt and might just help improve symptoms.

Warnings About Vitamins for Depression

First and foremost, if you believe you are suffering from depression, contact your doctor and make an appointment. Regardless of whether you want to try the best vitamin stack for depression, it’s important that you are under the care of a physician.

Make sure that you tell your doctor about any vitamins or supplements you’re taking as well. This is important in their ability to treat you. An accurate record of all over-the-counter meds, supplements, or herbal remedies you’re using can prevent drug interactions or other issues.

If you’re experiencing suicidal thoughts, please, do not hesitate to get help immediately. Go to any emergency room, call 1-800-273-8255 to speak to a professional and receive emotional support, or you can even get help by text. Send the word START to 741741.

As we’ve already mentioned, none of these supplements are a substitute for conventional care. Do not stop taking any medications without your doctor’s approval, and continue seeing your healthcare provider and mental health specialist. It can be dangerous to suddenly stop medications which influence the brain chemistry.

Finding the Best Supplement Stack for Depression

A good candidate for the best vitamin stack for depression should contain many, if not all, of the vitamins, minerals, and nutrients listed above. Look for supplements made by a reputable company who has their product third party tested for purity.

Check out our picks for the best vitamin stacks for depression below.

Our #1 Rated
Our pick our #1 rated

HCF

HCF Happy Calm Focused Brain Supplement

  • Quality
    Quality

  • Quality
    Price

  • Quality
    Our rating

This supplement contains all of the vitamins and minerals listed above except fish oil, plus amino acids that may also help depression sufferers. It is manufactured in a GMP (good manufacturing practice for pharmaceuticals) certified facility and comes in a capsule form.

Pros
Pro Many depression-fighting ingredients
Pro Also promotes sleep
Pro Non-stimulant
Pro Natural ingredients
Pro Amino acids targeting brain function
Cons
Con May cause heartburn in some users
Con At least 3 capsules a day
Con Capsules difficult to take
Con Some users do not notice any improvement
 

Our #2 Rated
Our pick our #2 rated

Arazo Nutrition

Brain Boost by BioScience Nutrition

  • Quality
    Quality

  • Quality
    Price

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This supplement, while aimed at overall brain health and function, contains many of the ingredients we’re looking for in a vitamin stack for depression. It uses a 41 ingredient formula.

Pros
Pro Made in FDA and GMP certified facility
Pro Free from major allergens
Pro No fillers
Pro Non-GMO
Pro No jitters
Cons
Con Contains many questionable herbal ingredients
Con Lower vitamin dosages than idea
Con Some ingredients may cause headaches
Con Requires a couple weeks to be effective
 

Our #3 Rated
Our pick our #3 rated

Nested Naturals

Natural Mood Lift by Nested Naturals

  • Quality
    Quality

  • Quality
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  • Quality
    Our rating

This supplement claims to enhance your mood by boosting serotonin levels. Made by a socially conscious company, this combination of B vitamins and amino acids is intended to help calm the mood.

Pros
Pro Lifetime guarantee
Pro Third party tested
Pro Contains magnesium
Pro Vegan
Pro Doesn’t make user feel tired
Cons
Con Large capsules
Con May cause indigestion
Con May cause stomach upset
Con Not effective for some users
 

Our #4 Rated
Our pick our #4 rated

InstantBrands

BoostMood Natural Mood Support

  • Quality
    Quality

  • Quality
    Price

  • Quality
    Our rating

This supplement contains herbal supplements and vitamin B12 to help improve mood. It claims to increase energy and promote the production of serotonin.

Pros
Pro Contains mood-boosting amino acids
Pro Herbal mood boosters
Pro Contains B12
Pro Aimed at improving serotonin production
Cons
Con Formulation may have changed
Con Difficult to swallow
Con May cause changes in appetite
Con Lacks vitamin and mineral support

Our #5 Rated
Our pick our #5 rated

LES Labs

Mood Boost by LES Labs

  • Quality
    Quality

  • Quality
    Price

  • Quality
    Our rating

Mood Boost contains many of the vitamins and minerals discussed above, as well as some unique herbal ingredients like passion flower. The combined effect of these substances is intended to decrease feelings of stress and anxiety and to improve overall mood.

Pros
Pro All natural ingredients
Pro Made in the US
Pro Two capsules per day
Pro Purity guaranteed
Pro Amino acids to improve mood
Cons
Con Contains largely untested herbal ingredients
Con May negatively affect libido
Con May make some users sleepy
Con May cause mood swings
 

Wrapping Up

The clear winner here of the best supplement stack for depression for us is the HCF Happy Calm Focused supplement. Though it is a relatively expensive solution, it takes a more scientific approach to aid in the treatment of depression and improve overall mood. Rather than herbs that may cause more problems than they solve, it uses vitamins and minerals that have been found to potentially help depressive patients.

Do you have any other questions about which vitamins, minerals, or other remedies might be good for depression? Don’t hesitate to ask! We’ll do our best to provide you with the facts.

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